{"id":7797,"date":"2025-07-18T08:16:00","date_gmt":"2025-07-18T01:16:00","guid":{"rendered":"https:\/\/www.globenewswire.com\/news-release\/2025\/07\/18\/3117701\/0\/en\/SAPU-Bioscience-Highlights-Peer-Reviewed-Publication-Linking-TGFB2-to-Survival-in-Younger-Pancreatic-Cancer-Patients.html3117701"},"modified":"2025-07-18T11:53:29","modified_gmt":"2025-07-18T04:53:29","slug":"sapu-bioscience-highlights-peer%e2%80%91reviewed-publication-linking-tgfb2-to-survival-in-younger-pancreatic-cancer-patients","status":"publish","type":"post","link":"https:\/\/cryptoinsider.asia\/vi\/sapu-bioscience-highlights-peer%e2%80%91reviewed-publication-linking-tgfb2-to-survival-in-younger-pancreatic-cancer-patients\/","title":{"rendered":"SAPU Bioscience Highlights Peer\u2011Reviewed Publication Linking TGFB2 to Survival in Younger Pancreatic Cancer Patients"},"content":{"rendered":"\n<p align=\"justify\"><strong>Data supports further evaluation of investigational antisense OT\u2011101 (trabedersen) as a TGFB2\u2011targeted approach in pancreatic ductal adenocarcinoma.<\/strong><\/p>\n<p align=\"justify\"><strong>SAN DIEGO, Calif., July 17, 2025 (GLOBE NEWSWIRE) &#8212; <\/strong>Sapu Biosciences, LLC (Sapu), a wholly owned subsidiary of GMP Biotechnology Limited (GMP Bio), in collaboration with Oncotelic Therapeutics, Inc. (OTCQB: OTLC) (Oncotelic), a clinical\u2011stage biopharmaceutical company developing RNA\u2011targeted and small\u2011molecule therapeutics for cancer and rare diseases, today highlighted the publication of new translational research evaluating TGFB2 expression and promoter methylation as potential prognostic markers in pancreatic ductal adenocarcinoma (PDAC). The article, <strong>\u201cTGFB2 Expression and Methylation Predict Overall Survival in Pancreatic Ductal Adenocarcinoma Patients,\u201d<\/strong> appears in the <em>International Journal of Molecular Sciences<\/em> (IJMS). The work involved investigators affiliated with <strong>Sapu.<\/strong><\/p>\n<p align=\"justify\"><strong>Access the publication:<\/strong> DOI 10.3390\/ijms26136357 (open access via <em>IJMS<\/em>).<\/p>\n<p align=\"justify\">Study Highlights<\/p>\n<p align=\"justify\"><strong>Clinical data from the OT<\/strong><strong>\u2011<\/strong><strong>101 P001 PDAC study suggest targeting TGFB2 merits additional evaluation in younger patients; in a treated subset characterized by low IL<\/strong><strong>\u2011<\/strong><strong>6, median OS was 12.7 months.<\/strong>\u2020<\/p>\n<p align=\"justify\">Investigator Commentary<\/p>\n<p align=\"justify\">\u201cThese findings give clinicians a practical way to stratify patients and design more precise, age focused trials, an urgently needed step toward improving outcomes in this notoriously lethal disease. OT-101, TGFB2 targeted approach deserves testing in randomized clinical trials,\u201d said <strong>Professor\u202fWasif\u202fSaif, MD<\/strong>, co-author of the study and Director of Eisenberg Center for Translational Therapeutics and Co-director of gastro-enterology Oncology Program at Karmanos Cancer Institute. He further added. \u201cAnalysis shows that high TGFB2 expression was significantly associated with reduced overall survival (OS) in patients under 65 (TGFB2 high median vs. low median OS: 17.9 vs. 66.9 months) but not in older cohorts. Moreover, elevated TGFB2 methylation showed improved survival in younger patients (high methylation vs. low methylation median OS: 66.9 vs. 17.9 months). Also, our clinical data from a Pancreatic Ductal Adenocarcinoma trial using OT-101, an antisense oligonucleotide targeting TGFB2, supported these findings that young patients treated with OT-101 showed improved OS compared to untreated controls. TGFB2 is not just another biomarker; its expression clearly delineates a younger subset of pancreatic cancer patients experiencing far poorer survival, and a patient population challenging clinicials more commonly over the last few years.\u201d<\/p>\n<p align=\"justify\">\u2020 Source: Company materials and the IJMS publication, <em>TGFB2 Expression and Methylation Predict Overall Survival in Pancreatic Ductal Adenocarcinoma Patients<\/em> (Saif <em>et al.<\/em> 2025).<\/p>\n<p align=\"justify\"><strong>Contact Information:<\/strong><\/p>\n<p align=\"justify\">For SAPU Bioscience LLC:<\/p>\n<p align=\"justify\">Investor Relations<\/p>\n<p align=\"justify\"><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=3Mv_ojOdLU3jWfQkkpfBu7SrApXk-lGw6rSSGpP6FkHLLm4JfRHSsssoyEkcwixCfdHOvt7PAZehrhXuFh-MvvjVJ8FvViM7pPRNdkuRFHJ_qGSUsQEJ4GQdcKU4_v9J\" rel=\"nofollow\" target=\"_blank\" title=\"investor.relations@sapubio.com\">investor.relations@sapubio.com<\/a><\/p>\n<p><img decoding=\"async\" alt src=\"https:\/\/ml.globenewswire.com\/media\/OGFiNGY3ZGMtM2JiOS00YjkzLTg2MzUtZGMzYTllYzcwMDlmLTUwMDE0OTU1NS0yMDI1LTA3LTE4LWVu\/tiny\/Sapu-Biosciences-LLC.png\" referrerpolicy=\"no-referrer-when-downgrade\">  <\/p>\n","protected":false},"excerpt":{"rendered":"<p> Data supports further evaluation of investigational antisense OT\u2011101 (trabedersen) as a TGFB2\u2011targeted approach in pancreatic ductal adenocarcinoma. SAN DIEGO, Calif., July 17, 2025 (GLOBE NEWSWIRE) &#8212; Sapu Biosciences, LLC (Sapu), a wholly owned subsidiary of GMP Biotechnology Limited (GMP Bio), in collaboration with Oncotelic Therapeutics, Inc. (OTCQB: OTLC) (Oncotelic), a clinical\u2011stage biopharmaceutical company developing RNA\u2011targeted and small\u2011molecule therapeutics for cancer and rare diseases, today highlighted the publication of new translational research evaluating TGFB2 expression and promoter methylation as potential prognostic&#8230;<\/p>\n","protected":false},"author":1,"featured_media":7798,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[75,1406],"tags":[],"class_list":["post-7797","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-business","category-globenewswire"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>SAPU Bioscience Highlights Peer\u2011Reviewed Publication Linking TGFB2 to Survival in Younger Pancreatic Cancer Patients<\/title>\n<meta name=\"description\" content=\"Data supports further evaluation of investigational antisense OT\u2011101 (trabedersen) as a TGFB2\u2011targeted approach in pancreatic ductal adenocarcinoma. SAN DIEGO, Calif., July 17, 2025 (GLOBE NEWSWIRE) -- Sapu Biosciences, LLC (Sapu), a wholly owned subsidiary of GMP Biotechnology Limited (GMP Bio), in collaboration with Oncotelic Therapeutics, Inc. (OTCQB: OTLC) (Oncotelic), a clinical\u2011stage biopharmaceutical company developing RNA\u2011targeted and small\u2011molecule therapeutics for cancer and rare diseases, today highlighted the publication of new translational research evaluating TGFB2 expression and promoter methylation as potential prognostic...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"\" \/>\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"SAPU Bioscience Highlights Peer\u2011Reviewed Publication Linking TGFB2 to Survival in Younger Pancreatic Cancer Patients\" \/>\n<meta property=\"og:description\" content=\"Data supports further evaluation of investigational antisense OT\u2011101 (trabedersen) as a TGFB2\u2011targeted approach in pancreatic ductal adenocarcinoma. SAN DIEGO, Calif., July 17, 2025 (GLOBE NEWSWIRE) -- Sapu Biosciences, LLC (Sapu), a wholly owned subsidiary of GMP Biotechnology Limited (GMP Bio), in collaboration with Oncotelic Therapeutics, Inc. (OTCQB: OTLC) (Oncotelic), a clinical\u2011stage biopharmaceutical company developing RNA\u2011targeted and small\u2011molecule therapeutics for cancer and rare diseases, today highlighted the publication of new translational research evaluating TGFB2 expression and promoter methylation as potential prognostic...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cryptoinsider.asia\/vi\/sapu-bioscience-highlights-peer\u2011reviewed-publication-linking-tgfb2-to-survival-in-younger-pancreatic-cancer-patients\/\" \/>\n<meta property=\"og:site_name\" content=\"Crypto Insider\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/yourcryptoinsider\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-18T01:16:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-18T04:53:29+00:00\" \/>\n<meta property=\"og:image\" 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